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COVAXX ANNOUNCES $2.8 BILLION IN ADVANCE PURCHASE COMMITMENTS TO DELIVER MORE THAN 140 MILLION VACCINE DOSES TO EMERGING COUNTRIES

COVAXX’s UB-612 is the only multitope, synthetic peptide vaccine candidate in the clinic
Company’s manufacturing facilities in place to produce 100 million doses in 1H 2021 and up to 1 billion by YE 2021
Vaccine (UB-612) distribution utilizes normal refrigeration (no freezing required)
Company partnered with Maersk for worldwide shipping and logistics
Phase 2/3 clinical trials to begin end of 2020/1Q 2021 in Asia, Latin America, and U.S.

HAUPPAUGE, NY (Nov. 25, 2020) – COVAXX, a U.S. company developing a multitope peptide-based vaccine to fight COVID-19, announces advanced purchase commitments of more than 140 million doses of its UB-612 vaccine, totaling over $2.8 billion, to deliver vaccines in multiple countries, including Brazil, Ecuador and Peru. These public and private commitments follow the start of human trials in Taiwan and the September agreement with Diagnosticos da America SA (Dasa S.A.), the largest clinical diagnostic company in Brazil, to conduct Phase 2/3 clinical trials and distribute vaccines within Brazil. 

“In parallel with the expedited clinical development of UB-612, we are working to help countries with the greatest unmet needs customize their plans for vaccine studies, supply and distribution,” said Mei Mei Hu, co-founder and CEO of COVAXX. “The realistic view of vaccine production is that we will need a wide range of vaccine options utilizing different technologies to meet worldwide demand. As much as vaccines matter, vaccinations matter more. To be administered effectively, vaccines need to demonstrate easy and affordable distribution, durability of response with the capability to further extend it with effective boosts, as well as the ability to adapt to a potential mutation in the virus while building on the first vaccines made available.”

COVAXX (not to be confused with single “x” COVAX) is currently completing Phase 1 clinical trials of UB-612 in Taiwan and has an agreement with the University of Nebraska Medical Center (UNMC), home of the National Pandemic Center, to also conduct trials in the U.S. Last month, COVAXX announced a global logistics partnership with Maersk, the world’s largest shipping and integrated logistics provider, that creates a framework for all transportation and supply chain services that will be needed to deliver COVAXX’s UB-612 around the world. 

“We applaud the progress of other vaccine developers, but recognize the global requirement for billions of doses,” said Dr. Peter H. Diamandis, COVAXX’s co-founder and vice-chairman. “Our vaccine has the following key attributes that make it potentially best in class: First, it is boostable. COVID-19 is not ‘one and done’ and populations will likely require boosters to protect against the virus. UB-612 technology has been shown to effectively boost repeatedly and without any side effects. Second, the vaccine is stable at 2-8C and can be delivered via existing distribution infrastrucure and normal refrigeration; Third, from preliminary data, UB-612 has observed minimal reactogenicity (i.e. no fevers, chills or systemic issues). While clinical efficacy data will be available during the next few months, we believe COVAXX is a best-in-class vaccine that is affordable and accessible for all earthlings.”

“The reality of vaccine manufacturing is that some vaccines will be available earlier than others, though in limited quantities and most likely available in the countries in which they are manufactured, as well as countries with a robust infrastructure and the financial ability to handle the complex cold-chain distribution,” said Lou Reese, COVAXX’s co-founder and executive chairman. “COVAXX is specifically focused on disrupting this traditional method. Our vaccine will be distributed globally, and our primary focus is on supplying emerging markets.”


About UB-612

UB-612 is a multitope vaccine designed to activate both B and T-cell arms of the immune system. UB-612 consists of the Spike protein S1 subunit Receptor Binding Domain (RBD) genetically fused to a single chain Fc domain of human IgG1 (S1-RBD-sFc), combined with proprietary peptides representing T helper (Th) and cytotoxic T-cell (CTL) epitopes on S2 subunit, Membrane and Nucleocapsid structural protein components of SARS-CoV-2. These Th and CTL peptides are selected based on their predicted binding to human MHC I and II, which would allow for the induction of memory recall and T-cell activation and effector functions. The vaccine candidate is formulated with CpG1 and aluminum phosphate (AdjuPhos®) to induce a Th1 prone response.
To date, preclinical studies in guinea pigs, rats and mice have shown that the UB-612 vaccine candidate generated extremely high titers of neutralizing antibodies with S1-RBD:hACE2 inhibition activities, as well as a balanced Th1/Th2 response toward the Th1 polarity.

About COVAXX

The mission of COVAXX is to democratize health and safeguard lives around the world by tackling the global COVID-19 pandemic using cost-effective, scalable and proven science-based solutions. COVAXX is developing a multitope peptide-based vaccine for COVID-19, which has shown promising preclinical safety and efficacy data and is based on a commercially proven, scalable vaccine platform.
COVAXX is a subsidiary of United Biomedical Inc (UBI), founded in 1985 and headquartered in New York. UBI has established a long legacy as a scientific trailblazer creating technological firsts, including the manufacture and commercialization of more than 100 million antibody blood diagnostic tests and 5 billion vaccine doses against infectious diseases in animal health. With exclusive access to UBI's core technology platforms, COVAXX can develop and commercialize high precision antibody tests and a promising COVID-19 vaccine that together would form a unique Differentiating Infected from Vaccinated Individuals (DIVI) system.

For more information, visit www.covaxx.com and follow us on social media:
Twitter @COVAXX_
Facebook @COVAXX
LinkedIn COVAXX
Instagram @covaxxvaxxine

Key Takeaways
  • Company’s manufacturing facilities in place to produce 100 million doses in 1H 2021 and up to 1 billion by YE 2021
  • Phase 2/3 clinical trials to begin end of 2020/1Q 2021 in Asia, Latin America, and U.S.
Quotes
“In parallel with the expedited clinical development of UB-612, we are working to help countries with the greatest unmet needs customize their plan...
Mei Mei Huco-Chief Executive Officer of COVAXX
“We applaud the progress of other vaccine developers, but recognize the global requirement for billions of doses. Our vaccine has the following key...
Peter Diamandis, M.D.co-Founder and Vice Chairman of COVAXX
“COVAXX is specifically focused on disrupting this traditional method. Our vaccine will be distributed globally, but our primary focus is on supply...
Lou Reeseco-Chief Executive Officer of COVAXX
Related Bios
Mei Mei Hu, JD
Co-Founder and Co-CEO
View Full Bio>>
Lou Reese
Co-Founder and Co-CEO
View Full Bio>>
Peter Diamandis, M.D.
co-Founder and Vice Chairman of COVAXX
View Full Bio>>
Contacts
Diane Murphy
diane@covaxx.com
(310) 658.8756
David Schull
David.Schull@russopartnersllc.com
2128454226
Media Relations
Thomas Boyd
thomas.h.boyd@maersk.com
7044303442
Maersk North America